Upcoming Events. It's a warm, friendly environment with slot machines. Must be 21+. 1. Seadust Cancun Family Resort · 6, reviews. Our New Mexico casino is open 24/7 daily. A warm and friendly environment with slot machines at the Main Casino. Swirls of Cash. Colorful bingo cards and round bingo balls w/numbers. The Pyramid Cancun · 4, reviews. No Smoking Facility. Win. The Travel center includes a casino area with 45 slot machines. With three live entertainment venues, you'll find something around every corner. . Unwind. Indulge. Sunday - Thursday: 8 AM - 2 AM | Friday & Saturday: Join the fun at Santa Ana Star Casino Hotel, the best casino in New Mexico! Located just north of Albuquerque, NM, we offer Gaming, Bowling, Golf, Dining. Saturdays in. #1 Best Value of 24 Mexico Casino Hotels ; 2. Excite. Experience Vegas at Albuquerque's Sandia Casino! Test your luck at our slots or play poker, roulette & more! High limit & VIP lounge available. #2 Best Value of 24 Mexico. DISCOVER NORTHERN NEW MEXICO AT ITS BEST! The casino is open every day. at Isleta Resort & Casino. Sky City Casino is open 24 hours daily. These casinos and gaming sites are owned by 14 New Mexico. Open 24 hours, 7 days a week! What's happening. Learn More. New Mexico has 23 Indian casinos and 4 Indian gaming travel centers located across 10 counties. Read More! Sky City's Main Casino and the Travel Center's Slot Area is open 24 hours daily.