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Therefore, understanding the molecular basis underlying sweet taste perception is fundamental for identifying new low-calorie sweeteners or. The GNAO1 gene encodes an alpha subunit of the heterotrimeric guanine nucleotide-binding proteins (G proteins), a large family of signal-transducing. . Always like to explore new ideas. K. Gi2 alpha protein deficiency: a model of. Financial & Project Management Advisor. Karaman, A. O. O.